P0683 - Mental Health Disorders in Inflammatory Bowel Disease - A Multi-Year Nationwide Analysis

Alexander Le, MD, Ayham Khrais, DO, Aaron Kahlam, MD, Yazan Abboud, MD
Rutgers New Jersey Medical School, Newark, NJ

Introduction: Anxiety, stress, and depressive symptoms are commonly identified to impact Inflammatory bowel disease (IBD) burden. It is associated with increased disease activity and health care costs, and reduced quality of life. This study investigates the prevalence of various mental health disorders in patients with IBD and compares them to patients without IBD.

Methods: A retrospective cohort study was conducted using the Nationwide Inpatient Sample from 2016-2019. All patients with a diagnosis of Ulcerative Colitis (UC) and Crohn's Disease (CD) aged greater than 18 years were included in the analysis using ICD-10 codes. ICD-10 codes were also used to identify mental health disorders including schizophrenia, depression, anxiety, obsessive compulsive disorder (OCD), trauma, disruptive and impulse control, suicidal ideation/attempt, neurodevelopmental. A univariate logistic regression was performed to calculate an odds ratio with a p-value < 0.05 as the significance cut off.

Results: A total of 99,840 patients were identified to have either UC or CD. IBD patients had a higher odds ratio of depression (OR 1.102; 95% CI, 1.081-1.123; p < 0.001), anxiety (OR 1.401; 95% CI, 1.377-1.425; p < 0.001), OCD (OR 1.255; 95% CI, 1.111-1.418; p < 0.001). IBD patients had a lower odds ratio of Schizophrenia (OR 0.411; 95% CI, 0.347-0.487; p < 0.001), Trauma (OR 0.853; 95% CI, 0.602-1.207; p < 0.368), Disruptive and Impulse Control, Conduct Disorders (OR 0.43; 95% CI, 0.324-0.571; p < 0.001), and Suicidal Ideation/Attempt (OR 0.279; 95% CI, 0.257-0.302; p < 0.001).

Discussion: Patients with IBD have a higher risk of having depression, anxiety, and OCD, but a lower risk for schizophrenia, trauma, and suicidal ideation/attempt. It is interesting that patients with IBD also have a lower risk of having a disruptive and impulse control disorder, which also includes eating disorders. Psychological disorders in IBD contributes to poor health-related quality of life, regardless of the severity of the condition. Screening for psychiatric conditions may prove useful in controlling IBD symptoms and disease burden.



Disclosures:


Alexander Le, MD, Ayham Khrais, DO, Aaron Kahlam, MD, Yazan Abboud, MD. P0683 - Mental Health Disorders in Inflammatory Bowel Disease - A Multi-Year Nationwide Analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.