P2129 - Analysis of Changes in the Incidence, Prevalence, Mortality, and Disability-Adjusted Life Years of Inflammatory Bowel Disease in the United States Between 2000-2019 Using the Global Burden of Diseases Database

Monday, October 23, 2023

10:30 AM – 4:15 PM PT

Location: Exhibit Hall

Presenting Author(s)

Saqr Alsakarneh, MD (he/him/his)

University of Missouri-Kansas City
Kansas City, MO

Saqr Alsakarneh, MD¹, Fouad Jaber, MD¹, Wael TAWFIC. Mohamed, MD¹, Yazan Abboud, MD², Mohamed Ahmed, MD³, Muhammad Shah Miran, MD¹, Hassan Ghoz, MD¹, Jana G.. Hashash, MD, MSc, FACG⁴, Francis A. Farraye, MD, MSc, MACG⁴
¹University of Missouri-Kansas City, Kansas City, MO; ²Rutgers New Jersey Medical School, Newark, NJ; ³University of Missouri Kansas City, Overland Park, KS; ⁴Mayo Clinic, Jacksonville, FL

Introduction: Inflammatory Bowel Disease (IBD) is an important cause of morbidity and mortality worldwide. Due to variable demographics among the US states, we aim to determine trends in the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) in the United States and across different states.

Methods: Using the Global Burden of Disease database, we analyzed the prevalence, incidence, mortality, and DALYs in the United States between 1990 and 2019. We computed relative percentage changes (RPC) over the study period and compared these between states.

Results: The overall age-standardized prevalence of IBD in the US has increased minimally from 192.4 per 100,000 population in 2000 to 193 per 100,000 population in 2019 (age-standardized RPC +0.3%). Illinois, Alabama, and North Carolina had the greatest increase in prevalence (+4.3%, +3.3%, and +2.9%) among all states. However, the District of Colombia, North Dakota, and California had the greatest decrease in prevalence (-3.5%, -3.3%, and -2.2%). The incidence of IBD increased in the US over the 30 years from 21.3 per 100,000 population in 2000 to 23.2 per 100,000 population in 2019 (RPC=+9.4%). North Dakota, South Dakota, and Ohio had the highest increase in incidence (+23.4%, +22.4%, and +22.2%). All states had an increase in the incidence of IBD except Nevada, where incidence rates decreased by -1.8% during the study period. The mortality rates increased in the US from 0.84 per 100,000 population in 2000 to 1.02 per 100,000 population in 2019 (RPC +21.4%). Tennessee, Iowa, and Kentucky had the highest increase in mortality (+39.6%, +39.1%, and +38.3%). Mortality rates increased in all states except Nevada (-2.5%). Women had a higher increase in IBD mortality than men (+24.1% vs. +21.7%). In the US, age-standardized DALYs increased for both genders, with a larger decrease for women than men (+8.1% vs. +6.1%).

Discussion: Overall, IBD incidence, prevalence, and mortality have increased significantly in the US since 2000. Urgent attention is necessary to address these changes and the geographical, socioeconomic, and sex disparities in mortality from IBD.

Figure: (A) Inflammatory Bowel Disease Prevalence Change (%) Between 2000-2019
(B) Inflammatory Bowel Disease Incidence Change (%) Between 2000-2019
(C) Inflammatory Bowel Disease Mortality Change (%) Between 2000-2019

	DALYs All ages Number 1990	DALYs All ages Number 2019	Change 2019/1990	DALYs Age-standardized rate 1990	DALYs Age-standardized rate 2019	Change 2019/1990
	DALYs All ages Number 1990	DALYs All ages Number 2019	Change 2019/1990	DALYs Age-standardized rate 1990	DALYs Age-standardized rate 2019	Change 2019/1990
Male	81412 (59751-107549)	92367 (73240-110534)	13.5%	65.8 (48.3-86.9)	57.3 (45.4-68.5)	-12.9%
Female	104945 (77694-136704)	122922 (99666-146519)	17.1%	80.9 (59.9-105.3)	73.7 (59.8-87.9)	-8.9%
Both	186357 (137531-243644)	215289 (175991-256059)	15.5%	73.5 (54.2-96.1)	65.6 (53.7-78.1)	-10.7%
	Deaths All ages Number 1990	Deaths All ages Number 2019	Change 2019/1990	Death Age-standardized rate 1990	Death Age-standardized rate 2019	Change 2019/1990
Male	825 (731-1174)	2315 (1607-2582)	180.6%	0.7 (0.6-0.9)	1.4 (1-1.6)	100.0%
Female	1346 (1176-1647)	3596 (2773-3966)	167.2%	1 (0.9-1.3)	2.2 (1.7-2.4)	120.0%
Both	2171 (1940-2662)	5910 (4622-6464)	172.2%	0.9 (0.8-1)	1.8 (1.4-2)	110.0%
	Incidence All ages Number 1990	Incidence All ages Number 2019	Change 2019/1990	Incidence Age-standardized rate 1990	Incidence Age-standardized rate 2019	Change 2019/1990
Male	47640 (40887-55039)	41506 (37932-45834)	-12.9%	38.5 (33-44.5)	25.7 (23.5-28.4)	-33.2%
Female	48873 (41984-57526)	43882 (39953-48871)	-10.2%	37.7 (32.3-44.3)	26.3 (24-29.3)	-30.2%
Both	96513 (83182-112507)	85388 (77956-94653)	-11.5%	38.1 (32.8-44.4)	26 (23.8-28.9)	-31.8%
	Prevalence All ages Number 1990	Prevalence All ages Number 2019	Change 2019/1990	Prevalence Age-standardized rate 1990	Prevalence Age-standardized rate 2019	Change 2019/1990
Male	435028 (373792-501730)	332233 (310460-354531)	-23.6%	351.4 (301.9-405.2)	206 (192.5-219.8)	-41.4%
Female	547954 (472643-629408)	430656 (402201-459131)	-21.4%	422.2 (364.2-484.9)	258.4 (241.3-275.4)	-38.8%
Both	982982 (846833-1129783)	762890 (712357-813654)	-22.4%	387.6 (333.9-445.5)	232.6 (217.2-248.1)	-40.0%
	YLDs All ages Number 1990	YLDs All ages Number 2019	Change 2019/1990	YLDs Age-standardized rate 1990	YLDs Age-standardized rate 2019	Change 2019/1990
Male	62292 (41039-87157)	47517 (32921-64112)	-23.7%	50.3 (33.1-70.4)	29.5 (20.4-39.7)	-41.4%
Female	80353 (53053-112250)	63186 (44158-84948)	-21.4%	61.9 (40.9-86.5)	37.9 (26.5-51)	-38.8%
Both	142645 (93978-199761)	110702 (76973-148846)	-22.4%	56.2 (37.1-78.8)	33.8 (23.5-45.4)	-39.9%
	YLLs All ages Number 1990	YLLs All ages Number 2019	Change 2019/1990	YLLs Age-standardized rate 1990	YLLs Age-standardized rate 2019	Change 2019/1990
Male	19120 (17258-26774)	44850 (31470-49131)	134.6%	15.4 (13.9-21.6)	27.8 (19.5-30.5)	80.5%
Female	24592 (22460-30495)	59737 (46718-64640)	142.9%	18.9 (17.3-23.5)	35.8 (28-38.8)	89.4%
Both	43712 (40217-54587)	104587 (82095-112252)	139.3%	17.2 (15.9-21.5)	31.9 (25-34.2)	85.5%

Disclosures:

Saqr Alsakarneh indicated no relevant financial relationships.

Fouad Jaber indicated no relevant financial relationships.

Wael Mohamed indicated no relevant financial relationships.

Yazan Abboud indicated no relevant financial relationships.

Mohamed Ahmed indicated no relevant financial relationships.

Muhammad Shah Miran indicated no relevant financial relationships.

Hassan Ghoz indicated no relevant financial relationships.

Jana Hashash: Iterative Health – Grant/Research Support.

Francis Farraye: AbbVie – Advisory Committee/Board Member. Avalo Therapeutics – Advisory Committee/Board Member. BMS – Advisory Committee/Board Member. Braintree Labs – Advisory Committee/Board Member. Fresenius Kabi – Advisory Committee/Board Member. GI Reviewers – Independent Contractor. GSK – Advisory Committee/Board Member. IBD Educational Group – Independent Contractor. Iterative Health – Advisory Committee/Board Member. Janssen – Advisory Committee/Board Member. Pfizer – Advisory Committee/Board Member. Pharmacosmos – Advisory Committee/Board Member. Sandoz Immunology – Advisory Committee/Board Member. Sebela – Advisory Committee/Board Member. Viatris – Advisory Committee/Board Member.

Saqr Alsakarneh, MD¹, Fouad Jaber, MD¹, Wael TAWFIC. Mohamed, MD¹, Yazan Abboud, MD², Mohamed Ahmed, MD³, Muhammad Shah Miran, MD¹, Hassan Ghoz, MD¹, Jana G.. Hashash, MD, MSc, FACG⁴, Francis A. Farraye, MD, MSc, MACG⁴. P2129 - Analysis of Changes in the Incidence, Prevalence, Mortality, and Disability-Adjusted Life Years of Inflammatory Bowel Disease in the United States Between 2000-2019 Using the Global Burden of Diseases Database, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.