P1347 - Comparing GERD Health-Related Quality of Life and Reflux Symptom Index Scores (RSI) in Patients With and Without Gastroparesis

Karan Sachdeva, MD¹, Nazar Hafiz, MD², Janak Bahirwani, MD³, Omar Khan, MD², Aditya Vyas, ², Syed Musa Raza, MD², Mohammad Alfrad Nobel Bhuiyan, PhD⁴, Hailey Canezaro, MS², Grace McCurdy, ², Francesca Weis, ⁵, Victoria Andrus, ², Elizabeth Armstrong, BA², Michelle Neice, MD², Maryam Mubashir, MD², Shazia Rashid, MD², Qiang Cai, MD, PhD, MACG^2
1Louisiana State University Health, Shreveport, LA; ²LSU Health Sciences Center, Shreveport, LA; ³St. Luke's University Health Network, Bethlehem, PA; ⁴Louisiana State University Health Sciences Center, Shreveport, LA; ⁵Louisiana State University Health Science, Shreveport, LA

Introduction: Gastro-esophageal reflux disease (GERD) is the most common gastrointestinal disorder globally that affects quality of life. Patients with refractory GERD are frequently subjected to testing, including upper endoscopy, wireless pH monitoring, 24-hour pH impedance monitoring, and management with endoscopic or surgical modalities like laparoscopic fundoplication. Gastroparesis has been suggested as one of the causes of refractory GERD. Presently there are no guidelines for performing a nuclear gastric emptying study as part of refractory GERD workup. We aimed to assess the difference in the GERD-related scores between patients who have a confirmed diagnosis of gastroparesis and the normal population.

Methods: 50 patients with a confirmed diagnosis of gastroparesis via a nuclear gastric emptying study who were planned for a gastric per-oral endoscopic myotomy (G-POEM) were enrolled in this study from September 2021 to November 2022. 50 patients without any symptoms or diagnosis of gastroparesis were used as controls from August 2022 to November 2022. Informed consent was obtained from all patients. All patients answered the GERD Health-related Quality of life [GERD-HQRL] (0-36, 36 being the worst) and Reflux Symptom Index scores [RSI] (0-40, 40 being the worst). Walch Two sample t-tests were conducted to assess if there was a statistically significant difference between the gastroparesis patients and non-gastroparesis patients for both GERD-HRQL and RSI scoring systems.

Results: The mean age of patients in the gastroparesis group and the non-gastroparesis group were 51.2 (72% females) and 54.2 (60% females), respectively. Patients diagnosed with gastroparesis exhibited significantly higher GERD-HRQL scores (Median: 18, IQR: 11-23) as compared to the general population cohort (Median: 4, IQR: 1-10) with a p-value < 0.001. Furthermore, the mean RSI scores of gastroparesis patients (Median: 15, IQR: 6.75-22) were significantly greater than the mean RSI scores of non-gastroparesis patients (Median: 3, IQR: 0-12) with a p-value < 0.001.

Discussion: The result shows that gastroparesis patients have significantly higher GERD-related scores than the normal population. However, further studies are warranted to elucidate the role of gastric emptying studies in patients with refractory GERD before considering more invasive and costly surgical or endoscopic GERD interventions.



Disclosures:


Karan Sachdeva, MD¹, Nazar Hafiz, MD², Janak Bahirwani, MD³, Omar Khan, MD², Aditya Vyas, ², Syed Musa Raza, MD², Mohammad Alfrad Nobel Bhuiyan, PhD⁴, Hailey Canezaro, MS², Grace McCurdy, ², Francesca Weis, ⁵, Victoria Andrus, ², Elizabeth Armstrong, BA², Michelle Neice, MD², Maryam Mubashir, MD², Shazia Rashid, MD², Qiang Cai, MD, PhD, MACG². P1347 - Comparing GERD Health-Related Quality of Life and Reflux Symptom Index Scores (RSI) in Patients With and Without Gastroparesis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.