P1250 - Characteristics and Associations of Celiac Disease in Minorities

Award: ACG Auxiliary Award (Trainee)

Award: Presidential Poster Award

Kara DiJoseph, DO¹, Scott Weismiller, MD², Paddy Ssentongo, MD¹, Shannon Dalessio, BA¹, Kofi Clarke, MD^3
1Penn State Hershey Medical Center, Hershey, PA; ²Hershey Medical Center, Hershey, PA; ³Penn State Health, Hershey, PA

Introduction: Celiac disease (CD) is a chronic immune disorder triggered by gluten exposure that damages the small intestine. Historically, CD was primarily classified as a disease of the Caucasian population. In 2015, a national survey revealed that 0.79% of the population was formally diagnosed with celiac disease, with the Non-Hispanic white population having a prevalence of 4-8 times higher than the underrepresented races. Although there is evidence that CD affects minorities at higher than reported rates, little data evaluates its consequences by race. Our study aimed to characterize celiac-related complications among underrepresented populations in a large health database.

Methods: We performed a cohort study among patients aged > 18, utilizing the TriNetX US Collaborative Network. Queries identified two cohorts of patients (minority and Non-Hispanic white) with CD (ICD-10 K90.0 and tTg ≥ 4) between 2016 and 2021. The minority cohort included patients with CD and a race/ethnicity categorized as Hispanic/Latino, American Indian/Alaska Native, Native Hawaiian/Other Pacific Islander, Asian or Black/African American. Cohorts were propensity score matched on age, sex, diabetes mellitus, chronic ischemic heart disease and chronic obstructive pulmonary disease. Outcomes were assessed up to one year after the index event (CD diagnosis), including vitamin/mineral deficiencies and hospital visits. Data were analyzed using the TriNetX Analytics function. IRB approval was not required because this study used existing de-identified data from the TriNetX database.

Results: Each group was matched with 817 patients. Compared to the Non-Hispanic White population, the minority group had a similar incidence of iron, vitamin B, and zinc deficiencies. The minority group had a higher risk of vitamin D deficiency, anemia secondary to iron deficiency, inpatient hospital stays, and emergency department visits.

Discussion: Our analysis shows evidence that minority patients with CD may have higher morbidity than non-Hispanic whites. This was particularly significant for vitamin D deficiency, anemia secondary to iron deficiency, inpatient hospital stays, and emergency department visits. While recognition of CD affecting minority populations is increasing, little is known about how its complications differentially impact these groups. Given the known morbidity associated with CD, future interventions should focus on mitigating the higher disease burden of the minority population.




Disclosures:


Kara DiJoseph, DO¹, Scott Weismiller, MD², Paddy Ssentongo, MD¹, Shannon Dalessio, BA¹, Kofi Clarke, MD³. P1250 - Characteristics and Associations of Celiac Disease in Minorities, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.